Many Patients Without GERD Continue to Take PPIs

More than 42% of patients with negative results from pH monitoring studies continue proton pump inhibitor (PPI) therapy, despite evidence that they do not have gastroesophageal reflux disease (GERD), according to the June issue of Clinical Gastroenterology and Hepatology.

PPI therapy is effective for about 75% of patients with GERD patients. However, if it fails to relieve symptoms, professional guidelines recommend pursuing endoscopy and ambulatory reflux testing to determine if patients have a different disorder that doesn’t respond to acid suppression. These patients should be managed by withdrawal of PPI therapy to see if the condition worsens, and a search for other diagnoses and treatments. However, little is known about whether physicians and patients take this approach.

Andrew J. Gawron et. al investigated the prevalence of continued use of PPIs among 90 patients whose results from endoscopic and Bravo pH or multichannel intraluminal impedance-pH (MII-pH) tests yielded negative results.

They found that 38 of the patients (42.2%) continued taking PPIs despite a negative result from a pH study. Only 17 (18.9%) recalled being instructed to stop taking PPIs; a chart review found that only 15 (16.7%) had documented evidence of being instructed to stop PPI therapy.

“Of those patients that kept taking a PPI, over a third were taking twice daily (or high-dose) therapy,” said Gawron in a video abstract that accompanied the article:

Andrew Gawron’s video abstract

Patients that kept taking the PPIs were more likely than those who stopped to report troublesome symptoms that affected their daily life.

The authors propose that many of the patients might be classified as having functional heartburn, based on the negative pH test results with continued symptoms.

“We think that our study reveals potential opportunities for clinicians to improve counseling after patients have negative [results] from pH testing,” said Gawron, proposing a more systematic approach to patients whose reflux testing yields negative results.

A recent cost-effectiveness analysis showed that early and increased use of pH monitoring could lead to less PPI use without a significant increase in cost to managed health care plans. However, testing alone is not sufficient if practitioners do not adequately communicate results to patients or patients don’t follow recommendations.

The authors add that it is possible that some of the patients might have symptoms from nonacid reflux. However, the prevalence of nonacid reflux has been reported to be ∼18%, leaving a substantial proportion of patients on PPI therapy without reflux disease (acid or nonacid).

Gawron et. al propose prospective studies to better stratify patients who respond poorly to PPIs based on physiological parameters and evaluate strategies to expedite diagnostic testing and improve follow-up analysis.

Read the article online. This article has accompanying CME activities.
Gawron AJ, Rothe J, Fought AJ, et al. Many patients continue using proton pump inhibitors after negative results from tests for reflux disease. Clin Gastroenterol Hepatol 2012;10:620–625.

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About Kristine Novak, PhD, Science Editor

Dr. Kristine Novak is the science editor for Gastroenterology and Clinical Gastroenterology and Hepatology, both published by the American Gastroenterological Association. She has worked as an editor at biomedical research journals and as a science writer for more than 12 years, covering advances in gastroenterology, hepatology, cancer, immunology, biotechnology, molecular genetics, and clinical trials. She has a PhD in cell biology and an interest in all areas of medical research.
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6 Responses to Many Patients Without GERD Continue to Take PPIs

  1. Pingback: Many Patients Without GERD Continue to Take PPIs | | Ha-PPi PPi Information

  2. JaneW says:

    Presumably, they can’t stop taking PPIs because they are physiologically dependent on them. Did anyone check the subjects’ gastrin levels?

  3. Andrew Gawron says:

    This is an interesting idea and we appreciate this comment. We did not measure gastrin levels on these patients as they were interviewed retrospectively and over the phone. The majority of patients never attempted to stop their PPI or were counseled to do so after negative test results, which we think is the major message of this paper. We cannot address whether or not these patients were somehow dependent on PPI therapy, although many of them described symptoms even on PPI therapy.

  4. Tracy Hill says:

    WHAT ABOUT CERTAIN FOODS, CAN THEY HELP WITH ACID REFLUX, BEING STRUGGLING FOR SEVERAL YEARS, DOCTOR SAYS TO TAKE NEXIUM BUT I READ THEY AND OTHER BRANDS SUCH AS PRILOSEC CAUSES BACTERIA INFECTION, HINCE I BEEN HAVING TROUBLE WITH AS WELL.

  5. MOHAMAD says:

    have these patients NERD?

  6. Pingback: Advancing Endoscopy – Easy to Start PPIs, Difficult to Stop?

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