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Author Archives: Kristine Novak, PhD, Science Editor
New Ways to Study HCV, Genotypes 3 and 4
Researchers can now study replication of Hepatitis C virus genotypes 3 and 4 in cultured cells, described in 2 articles in the January issue of Gastroenterology. These new tools will improve our understanding of how they cause liver disease, and … Continue reading
Posted in Basic Science, Practice
Tagged antiviral, assay, Cirrhosis, DAA, drug testing, experimental system, HCV, hepatitis C virus, in vitro, laboratory, liver disease, model, replication
2 Comments
Does Depression Increase the Risk for Inflammatory Bowel Disease?
Depression increases the risk for Crohn’s disease in women, according to a study published in the January issue of Clinical Gastroenterology and Hepatology. Psychological factors might therefore contribute to development of this disorder. Anxiety, depression, and other psychological disorders are … Continue reading
Posted in Basic Science, Practice
Tagged anxiety, causes, colitis, Crohn's Disease, database, depression, Genetics, IBD, Nurses' Health Study, population study, risk factor, stress
1 Comment
Why Do People Still Develop Colorectal Cancer After Colonoscopy?
Some people who receive screening colonoscopies are still at risk for colorectal cancer (CRC) because neoplastic polyps found are not completely removed, according to the January issue of Gastroenterology. While the quality of colonoscopy examinations has focused on polyp detection, … Continue reading
Posted in Practice
Tagged adenoma removal, cancer prevention, Colon Cancer, detection, incomplete resection, polyp, rate, Screening, Surgery, technique, Tumor
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Is it Safe for Patients With Cardiovascular Disease to Discontinue Low-Dose Aspirin Therapy?
In patients with cardiovascular disease, discontinuing low-dose aspirin therapy after peptic ulcer bleeding increases risk of death and acute cardiovascular events almost 7-fold, according to the January issue of Clinical Gastroenterology and Hepatology. Many patients with cardiovascular disease receive low-dose … Continue reading
Posted in Practice
Tagged age, baby aspirin, bleeding ulcer, gastrointestinal, heart attack, heart disease, ibuprofin, mortality, NSAID, risk
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What Causes Familial Visceral Myopathy?
A heterozygous variant in enteric smooth muscle actin γ-2 (ACTG2) can cause familial visceral myopathy (FVM), according to the December issue of Gastroenterology. The altered gene product appears to aggregate, rather than form actin filaments, in intestinal smooth muscle cells, disrupting … Continue reading
Posted in Basic Science
Tagged actin cytoskeleton, blockade, digestion problem, disease, filament, gene, Genetics, intestinal disease, motility, mutation, myosin
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Does a Response to Proton Pump Inhibitor Therapy Indicate GERD?
Just because a patient’s upper gastrointestinal symptoms are alleviated by proton pump inhibitors (PPIs) doesn’t necessarily mean that they have gastroesophageal reflux disease (GERD), according to the December issue of Clinical Gastroenterology and Hepatology. The efficacy of PPI therapy often … Continue reading
How do Intestinal Stem Cells get their Wnt?
Intestinal homeostasis and stem cells are not affected when Paneth cells stop producing Wnt, but Wnt is required to maintain the stem cell niche in intestinal epithelial cultures, according to a mouse study in the December issue of Gastroenterology. These … Continue reading
Posted in Basic Science
Tagged crypt, development, growth, intestine, Lgr, maintenance, mouse model, Paneth cell, stem cell, therapy, tissue regeneration, treatment, Wnt
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Why Does Colonoscopy Protect Against Left-Sided Cancers?
Polyps with advanced pathology are significantly smaller in the right than left colon, and are therefore more likely to be missed during colonoscopy examinations, according to the December issue of Clinical Gastroenterology and Hepatology. Mortality from colorectal cancer (CRC) is … Continue reading
Can We Prevent Portal Vein Thrombosis in Patients With Cirrhosis?
The anti-clotting agent enoxaparin prevents portal vein thrombosis (PVT) in patients with cirrhosis, according to the November issue of Gastroenterology. PVT can lead to portal hypertension and reduce the blood supply to the liver—some patients with acute or extensive PVT develop severe gastrointestinal … Continue reading
What Can Relieve Symptoms of Functional Dyspepsia?
Buspirone, an agonist of the serotonin receptor 5-HT1A, relaxes the proximal stomach to reduce symptoms of functional dyspepsia and increase gastric accommodation, according to trial results presented in the November issue of Clinical Gastroenterology and Hepatology. Functional dyspepsia is a … Continue reading
Posted in Practice
Tagged bloating, dyspepsia, fullness, meal, nitric oxide, pain, relaxation, stomach ache, stretch, volume
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Kristine Novak, PhD, Science Editor
