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Category Archives: Basic Science
How Can We Screen for Pancreatic Cancer and its Precursors?
Individuals with invasive pancreatic cancer or high-grade dysplasia can be identified based on a specific DNA mutation in pancreatic juice samples from the duodena, according to the June issue of Clinical Gastroenterology and Hepatology. Tests for mutant TP53 might be developed to improve the … Continue reading
How Does PSC Lead to IBD?
Many patients with primary sclerosing cholangitis (PSC) also have inflammatory bowel disease (IBD), which becomes more severe after liver transplantation, researchers report in the May issue of Clinical Gastroenterology and Hepatology. These patients might require special immunosuppressive regimens. PSC is … Continue reading
Fishing for Genes that Cause Biliary Atresia
A study of zebrafish has helped identify a susceptibility gene for biliary atresia, as reported in the May issue of Gastroenterology. Biliary atresia is a progressive fibro-inflammatory disorder of infants that involves the extrahepatic and intrahepatic biliary tree and causes … Continue reading
Posted in Basic Science
Tagged Animal Model, babies, biliiary tract, defect, gene, Genetics, hedgehog signaling, liver development, newborn, zebrafish
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What is Intrahepatic Cholangiocarcinoma?
Researchers have found that intrahepatic cholangiocarcinomas (ICCs) are really 2 different groups of tumors, based on molecular and genetic analyses, reported in the April issue of Gastroenterology. These findings identify class-specific mechanisms of oncogenesis that could lead to new treatment approaches … Continue reading
Posted in Basic Science
Tagged cancer-causing, cholangiocarcinoma, deletions, difference, Genetics, genomics, ICC, Liver Cancer, mechanisms, mutations, oncogenes, Oncogenesis, pathogenesis, Tumor
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A Rare, Autoimmune Cause of Intractable Nausea and Vomiting
Some cases of unexplained, intractable vomiting are caused by an autoimmune disorder in which patients develop antibodies against the brain protein astrocytic aquaporin-4 (AQP4), according to the March issue of Clinical Gastroenterology and Hepatology. AQP4 is a water channel in … Continue reading
Posted in Basic Science, Practice
Tagged autoimmune disease, brain, cause, etiology, nausea, nervous system, neurologic, neurology, pathogenesis, vomiting, water channel
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New Ways to Study HCV, Genotypes 3 and 4
Researchers can now study replication of Hepatitis C virus genotypes 3 and 4 in cultured cells, described in 2 articles in the January issue of Gastroenterology. These new tools will improve our understanding of how they cause liver disease, and … Continue reading
Posted in Basic Science, Practice
Tagged antiviral, assay, Cirrhosis, DAA, drug testing, experimental system, HCV, hepatitis C virus, in vitro, laboratory, liver disease, model, replication
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Kristine Novak, PhD, Science Editor
A Special Issue: the Exocrine Pancreas and its Disorders
Everything you ever wanted to know about the pancreas, its development and function, and the pathogenesis and treatment of its disorders are now covered in a special issue of Gastroenterology. Pancreatology is a rapidly developing field—recent findings from molecular and genetic … Continue reading →