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Category Archives: Basic Science
How Does Aspirin Prevent Cancer?
Aspirin blocks proliferation of colorectal cancer cells and causes them to self destruct by inhibiting the mechanistic target of rapamycin (mTOR), according to the June issue of Gastroenterology. Aspirin is a nonsteroidal anti-inflammatory drug that has been shown in many … Continue reading
Does the Western Diet Promote Endotoxemia and Inflammation?
A high-fat diet can cause endotoxemia, which promotes the systemic inflammation and metabolic disorders associated with obesity, according to a human study published in the May issue of Gastroenterology. Chronic endotoxemia (the presence of endotoxins such as lipopolysaccharide in blood) … Continue reading
Posted in Basic Science, Practice
Tagged adipose, calorie intake, cytokine, diabetes, gut microflora, high-fat diet, insulin resistance, intestinal inflammation, nutrition, Obesity
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A Special Issue on Viral Hepatitis
The May issue of Gastroenterology features a very special supplement—“Viral Hepatitis: A Changing Field”—comprising 17 review and commentary articles from international leaders in hepatitis treatment and research. The issue provides insight into the rapid progress made in the treatment and … Continue reading
Posted in Basic Science, Practice
Tagged Cirrhosis, editorial, HAV, HBV, HCV, hepatitis, HEV, perspective, review, therapy, treatment, Virology
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A Better Way to Make Pluripotent Cells From Liver Cells
Researchers have identified an efficient method for creating pluripotent stem cells from differentiated liver cells, according to the April issue of Gastroenterology. This technology could lead to new methods for therapeutic regeneration of diseased or damaged tissues. Embryonic stem cells … Continue reading
Why are Some Immunized Children Still At Risk for HBV Infection?
Despite immunization, children born to mothers with replicating HBV (marked by hepatitis B e antigen, or HBeAg) are still at risk for infection, according to the April issue of Gastroenterology. Mother-to-infant transmission is the major cause of hepatitis B virus … Continue reading
Posted in Basic Science, Practice
Tagged baby, Cirrhosis, HCC, hepatitis, mother to child transmission, mother-child, pediatric, Prevention, vaccination, vaccine
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What Causes Pancreatitis?
Trypsinogen might not be the sole culprit in acute pancreatitis, contradicting a century-old model of this disease; a new model is published in the December issue of Gastroenterology. Trypsinogen is a pancreatic protein that is converted in acinar cells to … Continue reading
Posted in Basic Science
Tagged chymotrypsin, Digestion, digestive enzyme, immune response, Inflammation, mouse model, Pancreas, pancreatitis, protease, tissue damage
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What Does the Appendix Do, Anyway?
The appendix protects against recurrent infection by Clostridium difficile (C difficile) and possibly other pathogenic bacteria, according to a study published in the December issue of Clinical Gastroenterology and Hepatology. Although the human appendix is considered to be expendable, it … Continue reading
Posted in Basic Science, Practice
Tagged appendix, B cells, clostridium difficile, Crohn's Disease, flora, IBD, immune regulation, inflammtory response, microbiota, pathogen
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Could Differences in Gut Bacteria Cause IBS?
The bacteria that reside in the intestines of adults and children with irritable bowel syndrome (IBS) differ from those of healthy adults and children, according to 2 studies in the November issue of Gastroenterology. Microorganisms account for 90% of the … Continue reading
Posted in Basic Science
Tagged abdominal pain, antibiotic effects, bacteria, bloating, causes, constipation, diarrhea, infection, probiotics, treatment, yogurt
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Kristine Novak, PhD, Science Editor
