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Tag Archives: mouse model
How do Intestinal Stem Cells get their Wnt?
Intestinal homeostasis and stem cells are not affected when Paneth cells stop producing Wnt, but Wnt is required to maintain the stem cell niche in intestinal epithelial cultures, according to a mouse study in the December issue of Gastroenterology. These … Continue reading
Posted in Basic Science
Tagged crypt, development, growth, intestine, Lgr, maintenance, mouse model, Paneth cell, stem cell, therapy, tissue regeneration, treatment, Wnt
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What Can We Learn from a Pig Model of FAP?
A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop … Continue reading
Posted in Basic Science
Tagged Animal Model, Colon Cancer, CRC, intestinal cancer, mechanism, mouse model, pathogenesis, preclinical, treatment, Tumor
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What Causes Pancreatitis?
Trypsinogen might not be the sole culprit in acute pancreatitis, contradicting a century-old model of this disease; a new model is published in the December issue of Gastroenterology. Trypsinogen is a pancreatic protein that is converted in acinar cells to … Continue reading
Posted in Basic Science
Tagged chymotrypsin, Digestion, digestive enzyme, immune response, Inflammation, mouse model, Pancreas, pancreatitis, protease, tissue damage
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Stem Cells Account for Different Fates of Adenomatous and Hyperplastic Polyps
Adenomatous polyps expand the pool of colon stem cells to become malignant, whereas hyperplastic polyps (HPPs) do not, and therefore remain benign, according to a study published in the September issue of Gastroenterology. Many colorectal cancers arise from adenomatous polyps, … Continue reading
Posted in Basic Science
Tagged adenomatous polyposis coli, BRAF, Cancer stem cell, cell cycle, cell growth, Colon Cancer, crypt, Genetics, KrasG12D, MEK, mouse model, neoplasm, oncogene, progression, proximal colon, rectal cancer, regulation, serrated, signal transduction, tumorigenesis
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An Immune Culprit in IBD?
Patients with Crohn’s disease or ulcerative colitis have reduced levels of an important regulator of the immune response—the receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF)—according to a study by Jonathan Goldstein et al. in the July issue of Gastroenterology. The inflammatory … Continue reading
Kristine Novak, PhD, Science Editor
A Special Issue: the Exocrine Pancreas and its Disorders
Everything you ever wanted to know about the pancreas, its development and function, and the pathogenesis and treatment of its disorders are now covered in a special issue of Gastroenterology. Pancreatology is a rapidly developing field—recent findings from molecular and genetic … Continue reading →