Who Has the Greatest Risk for Colorectal Cancer?

Men and smokers have the greatest risk for developing colorectal neoplasms—even more than people with a family history of this cancer—according to Michael Hoffmeister et al. in the October issue of Clinical Gastroenterology and Hepatology.

Current guidelines recommend that individuals with a family history of colorectal cancer (CRC), inflammatory bowel disease, or rare genetic syndromes be screened for colorectal cancer. Hoffmeister et al. looked for other factors that might contribute to risk, performing colonoscopies on 3349 individuals that had not previously received this type of screening. They investigated whether different types of polyps were associated with age, sex, education, body mass index, family history of cancer, or smoking.

They found that the population-attributable fraction of non-advanced and advanced neoplasias was highest for male sex (23%), followed by history of smoking (8%)—greater than for family history of CRC (3%). The prevalence of neoplasia was higher among non-smoking men than even women who smoke.

It is not clear why men have a much greater risk for colorectal neoplasia than women; the authors propose that differences in general health behavior and nutrition, in addition to biologic factors, might contribute.

CRC screening guidelines are already complex, but it is clear that sex and smoking history should be included as important determinants.

More Information on CRC:

What do you think? Use the “Leave a Comment” link below to post your thoughts.

Read the article online:
Hoffmeister M, Schmitz S, Karmrodt E, et al. Male sex and smoking have a larger impact on the prevalence of colorectal neoplasia than family history of colorectal cancer. Clin Gastroenterol and Hepatol 2010;10:870-876.

About Kristine Novak, PhD, Science Editor

Dr. Kristine Novak is the science editor for Gastroenterology and Clinical Gastroenterology and Hepatology, both published by the American Gastroenterological Association. She has worked as an editor at biomedical research journals and as a science writer for more than 12 years, covering advances in gastroenterology, hepatology, cancer, immunology, biotechnology, molecular genetics, and clinical trials. She has a PhD in cell biology and an interest in all areas of medical research.
This entry was posted in Cancer, GI Tract and tagged , , , . Bookmark the permalink.

2 Responses to Who Has the Greatest Risk for Colorectal Cancer?

  1. Freda says:

    I do not know whether it’s just me or if everyone else encountering issues with your blog. It looks like some of the written text on your posts are running off the screen. Can somebody else please provide feedback and let me know if this is happening to them as well? This could be a issue with my internet browser because I’ve had this happen before.

  2. I just like the helpful info you provide to your articles.
    I’ll bookmark your blog and test again here frequently.

    I’m fairly certain I’ll learn many new stuff right right here!

    Best of luck for the next!

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s