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Author Archives: Kristine Novak, PhD, Science Editor
What are Choledochoceles?
Choledochoceles are cystic dilatations of the intraduodenal portion of the common bile duct. They are often classified as Type III biliary cysts, but have distinct demographic and anatomic features, and a lower risk of malignancy than other types of choledochal … Continue reading
Posted in Liver/Biliary
Tagged abdominal pain, bile duct, biliary, Cancer, Choledochoceles, cyst, cystic dilatation, nausea, neoplasm, Pancreas, pancreatitis, vomiting
3 Comments
Sensitizing Colorectal Tumors to Chemotherapy
Although colorectal tumors with microsatellite instability (MSI) are usually considered to have a poor response to 5-fluorouracil–based chemotherapy, researchers have identified a subset that actually respond well to chemotherapy. These tumors express a dominant-negative form of the chaperone HSP110, according … Continue reading
Posted in Cancer, GI Tract
Tagged 5-FU, apoptosis, chemosensitization, chemotherapy, chromosome instability, Colon Cancer, genetic, MSI, pharmacogenetics, prognostic, response, survival
1 Comment
Is There a Way to Prevent Pancreatitis After ERCP?
Aggressive intravenous hydration with lactated Ringer’s solution reduces the incidence of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), but is not associated with volume overload, according to a pilot study published in the February issue of Clinical Gastroenterology and Hepatology. Pancreatitis … Continue reading
Posted in Pancreas, Technology
6 Comments
Are IBD Drugs Safe During Pregnancy?
Researchers find no evidence that inflammatory bowel disease (IBD) during pregnancy, or medical treatment for IBD during pregnancy, increases risk for congenital abnormalities in children. The findings, based on a large database analysis, are published in the January issue of Gastroenterology. … Continue reading
Posted in GI Tract, Technology
Tagged 5-ASA, AZA, birth defect, complication, Crohn's Disease, dangerous, drug, IBD, neonate, pregnancy, pregnant, risk factor, safety, steroid, therapy, treatment, Ulcerative Colitis
4 Comments
Most Popular Gastroenterology and CGH Papers from 2013
As we begin 2014, we can’t help but look back at 2013 and all the incredible discoveries that were made by gastroenterology and hepatology researchers. Based on the year’s most-downloaded original research articles from Gastroenterology and CGH, exciting things are … Continue reading
Can We Treat Diarrhea by Stimulating Na+ Absorption?
Drugs designed to increase intestinal absorption of sodium might be the best approach for treatment of diarrheal diseases, according to the Advances in Translational Science article in the January issue of Clinical Gastroenterology and Hepatology. Acute diarrheal diseases are the second … Continue reading
Posted in GI Tract, Technology
Tagged absorption, acute, brush border, chlorine, crypt, developing nations, diarrhea, drug development, exchange, intestine, mortality, sodium, treatment, villus
1 Comment
Mapping HCV Infection in the Liver
Using single-cell laser capture and high-resolution analysis, researchers show that hepatitis C virus (HCV) infects hepatocytes in the human liver in nonrandom clusters, whereas expression of anti-viral molecules is scattered among hepatocytes. The findings are presented in the December issue … Continue reading
Posted in Liver/Biliary
Tagged cell-cell, clinical specimen, control, HCV, hepatitis C, infection, ISG, liver, mechanism, microscopy, propagation, replication, spread, transmission, vRNA
4 Comments
Can We Increase Survival of Patients with Gastric Cancer?
Researchers have identified factors that affect life expectancy of patients with stomach cancer, reported in the December issue of Clinical Gastroenterology and Hepatology. Use of these factors to increase early detection of gastric adenocarcinoma could greatly increase survival times among … Continue reading
Posted in Cancer, GI Tract
Tagged adenocarcinoma, database, detection, Epidemiology, gastric, H pyori, life expectancy, mortality, risk factor, Stomach Cancer, survival, Taiwan cancer registry, treatment
1 Comment
How Does a High-Fat Diet Contribute to Pancreatic Cancer?
A high-fat diet can promote development of pancreatic cancer, but cyclooxygenase-2 (COX2) inhibitors prevent this process, according to a mouse study published in the December issue of Gastroenterology. The mechanisms appear to involve activation of oncogenic KRAS and upregulation of … Continue reading
Posted in Cancer, Pancreas
Tagged Celecoxib, COX2 inhibitor, diet, Fibrosis, Inflammation, mouse model, Obesity, Pancreatic cancer, PanIN, Prevention, risk factor, tumor progression
1 Comment
Putting a Cap on Acid Reflux
Researchers show that a polysaccharide ‘raft’ can float on top of acid in the stomach to block its backflow into the esophagus. It reduces reflux symptoms in patients with gastroesophageal reflux disease (GERD), according to a clinical trial the December issue … Continue reading
Posted in GI Tract, Technology
Tagged antacid, burning, esophagus, GERD, meal, medicine, post-prandial, reflux, stomach acid, therapy, treatment
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Kristine Novak, PhD, Science Editor
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