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Category Archives: Cancer
Video: Gastric to Esophageal Mucosal Transplantation
In the April issue of Gastroenterology, researchers report transplantation of mucosa from a patient’s stomach to esophagus, to prevent stricture formation after circumferential endoscopic mucosal dissection of early-stage esophageal cancer. Endoscopic submucosal resection and dissection are used to remove areas of dysplasia and … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged dissection, dysplasia, EMD, EMR, esophageal cancer, esophagus, gastric mucosa, resection, stomach, stricture prevention, Surgery, transplantation
1 Comment
What Patient Factors Affect Bowel Preparation for Colonoscopy?
Bowel preparation is suboptimal for about one third of adults older than 55 undergoing outpatient colonoscopy, says the March issue of Clinical Gastroenterology and Hepatology. Diabetes and low level of patient engagement in their own health care contribute to less-than-optimal … Continue reading
Posted in Cancer, Technology
Tagged bowel preparation, colon cleansing, efficacy, patient factors, safety
4 Comments
Sensitizing Colorectal Tumors to Chemotherapy
Although colorectal tumors with microsatellite instability (MSI) are usually considered to have a poor response to 5-fluorouracil–based chemotherapy, researchers have identified a subset that actually respond well to chemotherapy. These tumors express a dominant-negative form of the chaperone HSP110, according … Continue reading
Posted in Cancer, GI Tract
Tagged 5-FU, apoptosis, chemosensitization, chemotherapy, chromosome instability, Colon Cancer, genetic, MSI, pharmacogenetics, prognostic, response, survival
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Most Popular Gastroenterology and CGH Papers from 2013
As we begin 2014, we can’t help but look back at 2013 and all the incredible discoveries that were made by gastroenterology and hepatology researchers. Based on the year’s most-downloaded original research articles from Gastroenterology and CGH, exciting things are … Continue reading
Can We Increase Survival of Patients with Gastric Cancer?
Researchers have identified factors that affect life expectancy of patients with stomach cancer, reported in the December issue of Clinical Gastroenterology and Hepatology. Use of these factors to increase early detection of gastric adenocarcinoma could greatly increase survival times among … Continue reading
Posted in Cancer, GI Tract
Tagged adenocarcinoma, database, detection, Epidemiology, gastric, H pyori, life expectancy, mortality, risk factor, Stomach Cancer, survival, Taiwan cancer registry, treatment
1 Comment
How Does a High-Fat Diet Contribute to Pancreatic Cancer?
A high-fat diet can promote development of pancreatic cancer, but cyclooxygenase-2 (COX2) inhibitors prevent this process, according to a mouse study published in the December issue of Gastroenterology. The mechanisms appear to involve activation of oncogenic KRAS and upregulation of … Continue reading
Posted in Cancer, Pancreas
Tagged Celecoxib, COX2 inhibitor, diet, Fibrosis, Inflammation, mouse model, Obesity, Pancreatic cancer, PanIN, Prevention, risk factor, tumor progression
1 Comment
What is the Best Treatment for Esophageal Adenocarcioma?
Patients with esophageal adenocarcinoma (EAC) who receive endoscopic therapy survive as long as patients treated by surgery, according to the November issue of Clinical Gastroenterology and Hepatology. Esophageal cancer is a highly fatal malignancy—approximate 19% of patients survive 5 years. … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged adenocarcinoma, EAC, esophageal cancer, esophagus, morbidity, mortality, neoplasm, risk factor, Surgery, survival, therapy, treatment
2 Comments
Does Thiopurine Therapy Increase Cancer Risk?
Patients with ulcerative colitis (UC) have a 4-fold increase in risk of lymphoma during treatment with thiopurines, compared to UC patients who have not been treated with these drugs, according to a nationwide cohort study in the November issue of … Continue reading
Posted in Cancer, GI Tract
Tagged 6-mercaptopurine, azathioprine, cancer risk, colitis, DNA, EBV, IBD, immunosuppressant, Inflammatory Bowel Disease, lymphoma, purine, thiopurine
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What to do About Gastric Polyps
When clinicians detect a gastric polyp during endoscopy, they are faced with many questions: does the polyp need to be excised, or can a biopsy sample be collected and analyzed? Which polyps should be biopsied? Should patients then be followed, … Continue reading
Kristine Novak, PhD, Science Editor
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