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Category Archives: GI Tract
Special Issue: The Gut Microbiome
Gastroenterology is proud to present a special issue devoted to ‘The Gut Microbiome in Health and Disease’. The human body contains over 10 times more microbial cells than human cells. This microbiome (the commensal, symbiotic, and pathogenic microorganisms that share … Continue reading
Posted in GI Tract, Technology Tagged bacteria, C difficile, disease, E coli, gut, health, immune regulation, intestinal, liver, microbiome, microbiota, microorganism 1 Comment
Video: Gastric to Esophageal Mucosal Transplantation
In the April issue of Gastroenterology, researchers report transplantation of mucosa from a patient’s stomach to esophagus, to prevent stricture formation after circumferential endoscopic mucosal dissection of early-stage esophageal cancer. Endoscopic submucosal resection and dissection are used to remove areas of dysplasia and … Continue reading
Posted in Cancer, GI Tract, Technology Tagged dissection, dysplasia, EMD, EMR, esophageal cancer, esophagus, gastric mucosa, resection, stomach, stricture prevention, Surgery, transplantation 1 Comment
How Many People Have Eosinophilic Esophagitis?
Eosinophilic esophagitis (EoE), which was barely recognized 20 years ago, affects at least 150,000 people in the United States, with three-quarters being adults, report Evan Dellon et al. in the April issue of Clinical Gastroenterology and Hepatology. EoE, also known … Continue reading
Posted in GI Tract Tagged allergy, EoE, Eosinophilic Esophagitis, eosinophils, Epidemiology, food, immune response, incidence, population study, prevalence, swallowing 1 Comment
Preventing Hypoglycemia After Gastric Bypass
Many patients who undergo gastric bypass surgery experience hypoglycemia after meals. Researchers report in the March issue of Gastroenterology that they can correct this condition with an agent that blocks the receptor for the glucagon-like peptide 1 (GLP1). Roux-en-Y gastric bypass … Continue reading
Posted in GI Tract Tagged blood sugar level, diabetes, glucose, glycemia, insulin, intestine, islet cell, L cell, Pancreas, Roux-en-Y gastric bypass surgery, side-effect, Weight Loss 1 Comment
In Treating Crohn’s Disease, Earlier is Better
Patients receiving medical therapies when they have more complicated stages of Crohn’s disease (CD) are more likely to require surgery, researchers report in the March issue of Clinical Gastroenterology and Hepatology. The disease is most-effectively treated by drugs at its … Continue reading
Posted in GI Tract Tagged anti-TNF, CD, drug, early, IBD, Inflammation, Inflammatory Bowel Disease, late-stage, progression, stricture, sugery, thiopurine, TNF inhibitors, treatment 1 Comment
How Does an Antibiotic Reduce Symptoms of IBS?
Rifaximin alters the intestinal microbiota to prevent inflammation and visceral hyperalgesia in stressed rats, according to the February issue of Gastroenterology. These findings could explain the ability of this antibiotic to relieve symptoms of irritable bowel syndrome (IBS) in patients. … Continue reading
Sensitizing Colorectal Tumors to Chemotherapy
Although colorectal tumors with microsatellite instability (MSI) are usually considered to have a poor response to 5-fluorouracil–based chemotherapy, researchers have identified a subset that actually respond well to chemotherapy. These tumors express a dominant-negative form of the chaperone HSP110, according … Continue reading
Posted in Cancer, GI Tract Tagged 5-FU, apoptosis, chemosensitization, chemotherapy, chromosome instability, Colon Cancer, genetic, MSI, pharmacogenetics, prognostic, response, survival 1 Comment
Are IBD Drugs Safe During Pregnancy?
Researchers find no evidence that inflammatory bowel disease (IBD) during pregnancy, or medical treatment for IBD during pregnancy, increases risk for congenital abnormalities in children. The findings, based on a large database analysis, are published in the January issue of Gastroenterology. … Continue reading
Posted in GI Tract, Technology Tagged 5-ASA, AZA, birth defect, complication, Crohn's Disease, dangerous, drug, IBD, neonate, pregnancy, pregnant, risk factor, safety, steroid, therapy, treatment, Ulcerative Colitis 4 Comments
Most Popular Gastroenterology and CGH Papers from 2013
As we begin 2014, we can’t help but look back at 2013 and all the incredible discoveries that were made by gastroenterology and hepatology researchers. Based on the year’s most-downloaded original research articles from Gastroenterology and CGH, exciting things are … Continue reading
Posted in Cancer, GI Tract, Liver/Biliary, Pancreas, Technology Tagged FODMAP 2 Comments
Can We Treat Diarrhea by Stimulating Na+ Absorption?
Drugs designed to increase intestinal absorption of sodium might be the best approach for treatment of diarrheal diseases, according to the Advances in Translational Science article in the January issue of Clinical Gastroenterology and Hepatology. Acute diarrheal diseases are the second … Continue reading
Posted in GI Tract, Technology Tagged absorption, acute, brush border, chlorine, crypt, developing nations, diarrhea, drug development, exchange, intestine, mortality, sodium, treatment, villus 1 Comment