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Category Archives: Pancreas
Is There a Way to Prevent Pancreatitis After ERCP?
Aggressive intravenous hydration with lactated Ringer’s solution reduces the incidence of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), but is not associated with volume overload, according to a pilot study published in the February issue of Clinical Gastroenterology and Hepatology. Pancreatitis … Continue reading
Posted in Pancreas, Technology
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Most Popular Gastroenterology and CGH Papers from 2013
As we begin 2014, we can’t help but look back at 2013 and all the incredible discoveries that were made by gastroenterology and hepatology researchers. Based on the year’s most-downloaded original research articles from Gastroenterology and CGH, exciting things are … Continue reading
How Does a High-Fat Diet Contribute to Pancreatic Cancer?
A high-fat diet can promote development of pancreatic cancer, but cyclooxygenase-2 (COX2) inhibitors prevent this process, according to a mouse study published in the December issue of Gastroenterology. The mechanisms appear to involve activation of oncogenic KRAS and upregulation of … Continue reading
Posted in Cancer, Pancreas
Tagged Celecoxib, COX2 inhibitor, diet, Fibrosis, Inflammation, mouse model, Obesity, Pancreatic cancer, PanIN, Prevention, risk factor, tumor progression
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A New Way to Detect Pancreatic Tumors?
Researchers have developed an ultrasound technique to image pancreatic tumors in mice, described in the October issue of Gastroenterology. This approach might useful in early detection of pancreatic ductal adenocarcinoma (PDAC). PDAC is the fourth leading cause of cancer death … Continue reading
How Can We Screen for Pancreatic Cancer and its Precursors?
Individuals with invasive pancreatic cancer or high-grade dysplasia can be identified based on a specific DNA mutation in pancreatic juice samples from the duodena, according to the June issue of Clinical Gastroenterology and Hepatology. Tests for mutant TP53 might be developed to improve the … Continue reading
Can We Increase the Sensitivity of Pancreatic Cancer Cells to Chemotherapeutics?
Researchers have identified small molecules that increase the ability of chemotherapeutic agents to kill pancreatic cancer cells and slow tumor growth in mice, according to the February issue of Gastroenterology. One way that chemotherapeutics such gemcitabine, 5-fluorouracil, and platinum-based compounds … Continue reading
Posted in Cancer, Pancreas, Technology
Tagged chemotherapy, drug, efficacy, Pancreatic cancer, response, safety, sensitivity, therapy, treatment
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Kristine Novak, PhD, Science Editor
agajournals.wordpress.com 
A Special Issue: the Exocrine Pancreas and its Disorders
Everything you ever wanted to know about the pancreas, its development and function, and the pathogenesis and treatment of its disorders are now covered in a special issue of Gastroenterology. Pancreatology is a rapidly developing field—recent findings from molecular and genetic … Continue reading →