Tag Archives: Clinical Trial

A New Drug for Diabetes and Fatty Liver Disease?

Obeticholic acid (OCA)—an agonist of the farnesoid X receptor (FXR)— increases insulin sensitivity and reduces markers of liver inflammation and fibrosis in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), according to a study published in … Continue reading

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A More Effective Treatment for Achalasia

A specialized endoscopic procedure called peroral endoscopic myotomy (POEM) is a safe and effective treatment for esophageal achalasia, according to the August issue of Gastroenterology. Achalasia is an esophageal motility disorder characterized by incomplete relaxation of the lower esophageal sphincter, … Continue reading

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Long-Term Effects of Teduglutide for Short-Bowel Syndrome

The glucagon-like peptide (GLP) teduglutide is effective for long-term treatment of patients with short-bowel syndrome intestinal failure, according to the July issue of Clinical Gastroenterology and Hepatology. Short-bowel syndrome is a relatively rare condition that results from massive small bowel … Continue reading

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Is SVR12 As Good As SVR24?

In patients with chronic Hepatitis C virus (HCV) infection, a sustained viral response to treatment regimens 12 weeks after therapy (SVR12) is a good indicator that the response will be maintained until week 24 (SVR 24), based on an analysis of … Continue reading

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Can We Prevent Portal Vein Thrombosis in Patients With Cirrhosis?

The anti-clotting agent enoxaparin prevents portal vein thrombosis (PVT) in patients with cirrhosis, according to the November issue of Gastroenterology. PVT can lead to portal hypertension and reduce the blood supply to the liver—some patients with acute or extensive PVT develop severe gastrointestinal … Continue reading

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Could Intestinal Microbes Reduce Insulin Resistance?

The intestinal microbiota can be manipulated to increase insulin sensitivity in people with metabolic syndrome, according to a study published in the October issue of Gastroenterology. The trillions of microorganisms that reside in the human intestine are important regulators of … Continue reading

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Treating Rumination and Supragastric Belching

Baclofen is an effective treatment for patients with rumination or supragastric belching/aerophagia, according to the April issue of Clinical Gastroenterology and Hepatology. Rumination syndrome is characterized by the effortless, often repetitive regurgitation of recently ingested food into the mouth; it … Continue reading

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