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Tag Archives: Colon Cancer
Sensitizing Colorectal Tumors to Chemotherapy
Although colorectal tumors with microsatellite instability (MSI) are usually considered to have a poor response to 5-fluorouracil–based chemotherapy, researchers have identified a subset that actually respond well to chemotherapy. These tumors express a dominant-negative form of the chaperone HSP110, according … Continue reading
Posted in Cancer, GI Tract
Tagged 5-FU, apoptosis, chemosensitization, chemotherapy, chromosome instability, Colon Cancer, genetic, MSI, pharmacogenetics, prognostic, response, survival
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Are All Patients With IBD at Increased Risk for Colorectal Cancer?
Although inflammatory bowel disease (IBD) increases risk for colorectal cancer (CRC), the risk is only substantial among patients with long-term, extensive colitis. Furthermore, CRC risk is reduced by thiopurine therapy, according to the July issue of Gastroenterology. Laurent Beaugerie et … Continue reading
Posted in Cancer, GI Tract
Tagged CD, Colon Cancer, Colorectal Cancer, CRC, Crohn's Disease, Epidemiology, IBD, Inflammatory Bowel Disease, risk factor, UC, Ulcerative Colitis
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What are the Risks for Relatives of Patients With Colorectal Cancer?
Close relatives of people with colorectal cancer (CRC) have a significant increase in prevalence of advanced neoplasms and should be screened for cancer, according to the March issue of Gastroenterology. Relatives of patients with CRC have been shown to be … Continue reading
Posted in Cancer, GI Tract
Tagged Adenoma, cancer family, Colon Cancer, colonoscopy screening, Colorectal Cancer, CRC, familial, Genetics, inherited, polyp, Prevention, risk factor, Tumor
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Why Do People Still Develop Colorectal Cancer After Colonoscopy?
Some people who receive screening colonoscopies are still at risk for colorectal cancer (CRC) because neoplastic polyps found are not completely removed, according to the January issue of Gastroenterology. While the quality of colonoscopy examinations has focused on polyp detection, … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged adenoma removal, cancer prevention, Colon Cancer, detection, incomplete resection, polyp, rate, Screening, Surgery, technique, Tumor
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What Can We Learn from a Pig Model of FAP?
A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged Animal Model, Colon Cancer, CRC, intestinal cancer, mechanism, mouse model, pathogenesis, preclinical, treatment, Tumor
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Stem Cells Account for Different Fates of Adenomatous and Hyperplastic Polyps
Adenomatous polyps expand the pool of colon stem cells to become malignant, whereas hyperplastic polyps (HPPs) do not, and therefore remain benign, according to a study published in the September issue of Gastroenterology. Many colorectal cancers arise from adenomatous polyps, … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged adenomatous polyposis coli, BRAF, Cancer stem cell, cell cycle, cell growth, Colon Cancer, crypt, Genetics, KrasG12D, MEK, mouse model, neoplasm, oncogene, progression, proximal colon, rectal cancer, regulation, serrated, signal transduction, tumorigenesis
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Who Will Develop Colorectal Cancer at a Young Age?
A screen for mutations in mismatch repair (MMR) genes could be used to identify young people at risk for colorectal cancer, report Paul Limburg et al. in the June issue of Clinical Gastroenterology and Hepatology. It is a challenge to … Continue reading
Posted in Cancer, GI Tract
Tagged cancer risk, Colon Cancer, DNA mismatch repair genes, early-onset, Genetics, mutant, risk, susceptibility
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Anti-Inflammatory Drugs Prevent Colorectal Cancer (for Some)
Aspirin and other anti-inflammatory drugs prevent colorectal cancer (CRC) in some people but not others, according to the March issue of Gastroenterology. Andrew Chan et al. found that these drugs reduce the risk of CRC only in women with high … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged Chemoprevention, Colon Cancer, Inflammation, Prevention
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Kristine Novak, PhD, Science Editor
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