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Kristine Novak, PhD, Science Editor
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Tag Archives: crypt
Can We Treat Diarrhea by Stimulating Na+ Absorption?
Drugs designed to increase intestinal absorption of sodium might be the best approach for treatment of diarrheal diseases, according to the Advances in Translational Science article in the January issue of Clinical Gastroenterology and Hepatology. Acute diarrheal diseases are the second … Continue reading
Posted in GI Tract, Technology
Tagged absorption, acute, brush border, chlorine, crypt, developing nations, diarrhea, drug development, exchange, intestine, mortality, sodium, treatment, villus
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How do Intestinal Stem Cells get their Wnt?
Intestinal homeostasis and stem cells are not affected when Paneth cells stop producing Wnt, but Wnt is required to maintain the stem cell niche in intestinal epithelial cultures, according to a mouse study in the December issue of Gastroenterology. These … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged crypt, development, growth, intestine, Lgr, maintenance, mouse model, Paneth cell, stem cell, therapy, tissue regeneration, treatment, Wnt
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Stem Cells Account for Different Fates of Adenomatous and Hyperplastic Polyps
Adenomatous polyps expand the pool of colon stem cells to become malignant, whereas hyperplastic polyps (HPPs) do not, and therefore remain benign, according to a study published in the September issue of Gastroenterology. Many colorectal cancers arise from adenomatous polyps, … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged adenomatous polyposis coli, BRAF, Cancer stem cell, cell cycle, cell growth, Colon Cancer, crypt, Genetics, KrasG12D, MEK, mouse model, neoplasm, oncogene, progression, proximal colon, rectal cancer, regulation, serrated, signal transduction, tumorigenesis
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