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Tag Archives: Fibrosis
What is the Best Way to Care for Patients with Alcoholic Hepatitis?
Although alcohol-related liver disease is the 8th most common cause of mortality in the US and the 2nd leading cause of mortality among all gastrointestinal diseases, there are few therapeutic options for patients or resources to support identification of new … Continue reading
Posted in Liver/Biliary
Tagged alcohol, alcoholic, Cirrhosis, damage, drugs, ethanol, Fibrosis, hepatocyte, immune response, Inflammation, Kupfer cell, liver disease, therapy, treatment
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How Does a High-Fat Diet Contribute to Pancreatic Cancer?
A high-fat diet can promote development of pancreatic cancer, but cyclooxygenase-2 (COX2) inhibitors prevent this process, according to a mouse study published in the December issue of Gastroenterology. The mechanisms appear to involve activation of oncogenic KRAS and upregulation of … Continue reading
Posted in Cancer, Pancreas
Tagged Celecoxib, COX2 inhibitor, diet, Fibrosis, Inflammation, mouse model, Obesity, Pancreatic cancer, PanIN, Prevention, risk factor, tumor progression
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Are Patients Receiving the Latest Anti-HCV Drugs?
Less than 20% of patients infected with the most common Hepatitis C virus (HCV) genotype receive the latest drugs approved by the US Food and Drug Administration (FDA), according to the August issue of Clinical Gastroenterology and Hepatology. This low … Continue reading
Posted in Liver/Biliary, Technology
Tagged Cirrhosis, clinical tirial, DAA, direct-acting anti-viral agent, drug, Fibrosis, HCV, hepatitis, liver, patient management, therapy, treatment, virus
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Can We Prevent Portal Vein Thrombosis in Patients With Cirrhosis?
The anti-clotting agent enoxaparin prevents portal vein thrombosis (PVT) in patients with cirrhosis, according to the November issue of Gastroenterology. PVT can lead to portal hypertension and reduce the blood supply to the liver—some patients with acute or extensive PVT develop severe gastrointestinal … Continue reading
Differences in HCV Infection, and Effects of Treatment, Among Countries
Hepatitis C virus (HCV) infections have developed and spread at different rates in different countries, affecting outcomes of therapy, according to the October issue of Gastroenterology. Specific details of each population must therefore be considered in designing prevention and treatment … Continue reading
Posted in Liver/Biliary
Tagged Cirrhosis, disease progression, Epidemiology, Europe, Fibrosis, hepatitis, Liver Cancer, liver disease, transplant, United States
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How Common is Portal Hypertension in Patients With NAFLD?
Patients with nonalcoholic fatty liver disease (NAFLD) are at risk for portal hypertension and esophageal varices, according to the September issue of Clinical Gastroenterology and Hepatology. The study also shows that factors such as advanced liver disease, type 2 diabetes, … Continue reading
Posted in GI Tract, Liver/Biliary
Tagged Cirrhosis, disease progression, fatty liver disease, Fibrosis, Inflammation, liver disease, NAFLD, NASH, Obesity, Prevention, risk factor
5 Comments
What Factors Predict Recovery From Chronic HBV Infection?
A low and rapidly decreasing level of Hepatitis B surface antigen (HBsAg) is a good sign for patients with chronic HBV infection, according to the March issue of Clinical Gastroenterology and Hepatology. Tracking progression of chronic HBV infection can be … Continue reading
Posted in Liver/Biliary
Tagged Cirrhosis, cure, Fibrosis, HCC, hepatitis, liver disease, prognosis, recovery, treatment, virus
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Can We Treat Chronic HCV Infection Without Interferon?
A potent combination of 2 drugs that directly target the hepatitis C virus (HCV) is effective in patients with chronic infection, and doesn’t require interferon therapy, according to an article in the December issue of Gastroenterology. Patients infected with HCV … Continue reading
Posted in Liver/Biliary, Technology
Tagged Cirrhosis, Clinical Trial, DAA, direct acting antiviral agent, drug development, Fibrosis, HCV, hepatitis C, liver disease, therapy
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As Incidence of HCV Infection Increases, a New Mouse Model to Study
The incidence of hepatitis C virus (HCV) infection and its complications—hepatocellular carcinoma (HCC) and cirrhosis—are increasing, according to Fasiha Kanwal et al. Fortunately, a new mouse model has been created to study disease progression and treatment, as described by Michael … Continue reading
Posted in Liver/Biliary, Technology
Tagged Animal Model of Hepatitis, Cancer, Epidemiology, Fibrosis, Human Immunology, Virology
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Kristine Novak, PhD, Science Editor
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