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Tag Archives: Genetics
Fishing for Genes that Cause Biliary Atresia
A study of zebrafish has helped identify a susceptibility gene for biliary atresia, as reported in the May issue of Gastroenterology. Biliary atresia is a progressive fibro-inflammatory disorder of infants that involves the extrahepatic and intrahepatic biliary tree and causes … Continue reading
Posted in Liver/Biliary, Technology Tagged Animal Model, babies, biliiary tract, defect, gene, Genetics, hedgehog signaling, liver development, newborn, zebrafish 4 Comments
What is Intrahepatic Cholangiocarcinoma?
Researchers have found that intrahepatic cholangiocarcinomas (ICCs) are really 2 different groups of tumors, based on molecular and genetic analyses, reported in the April issue of Gastroenterology. These findings identify class-specific mechanisms of oncogenesis that could lead to new treatment approaches … Continue reading
Posted in Cancer, Liver/Biliary Tagged cancer-causing, cholangiocarcinoma, deletions, difference, Genetics, genomics, ICC, Liver Cancer, mechanisms, mutations, oncogenes, Oncogenesis, pathogenesis, Tumor 2 Comments
What are the Risks for Relatives of Patients With Colorectal Cancer?
Close relatives of people with colorectal cancer (CRC) have a significant increase in prevalence of advanced neoplasms and should be screened for cancer, according to the March issue of Gastroenterology. Relatives of patients with CRC have been shown to be … Continue reading
Posted in Cancer, GI Tract Tagged Adenoma, cancer family, Colon Cancer, colonoscopy screening, Colorectal Cancer, CRC, familial, Genetics, inherited, polyp, Prevention, risk factor, Tumor 1 Comment
Does Depression Increase the Risk for Inflammatory Bowel Disease?
Depression increases the risk for Crohn’s disease in women, according to a study published in the January issue of Clinical Gastroenterology and Hepatology. Psychological factors might therefore contribute to development of this disorder. Anxiety, depression, and other psychological disorders are … Continue reading
Posted in GI Tract Tagged anxiety, causes, colitis, Crohn's Disease, database, depression, Genetics, IBD, Nurses' Health Study, population study, risk factor, stress 2 Comments
What Causes Familial Visceral Myopathy?
A heterozygous variant in enteric smooth muscle actin γ-2 (ACTG2) can cause familial visceral myopathy (FVM), according to the December issue of Gastroenterology. The altered gene product appears to aggregate, rather than form actin filaments, in intestinal smooth muscle cells, disrupting … Continue reading
Posted in Cancer, GI Tract Tagged actin cytoskeleton, blockade, digestion problem, disease, filament, gene, Genetics, intestinal disease, motility, mutation, myosin Leave a comment
Stem Cells Account for Different Fates of Adenomatous and Hyperplastic Polyps
Adenomatous polyps expand the pool of colon stem cells to become malignant, whereas hyperplastic polyps (HPPs) do not, and therefore remain benign, according to a study published in the September issue of Gastroenterology. Many colorectal cancers arise from adenomatous polyps, … Continue reading
Posted in Cancer, GI Tract, Technology Tagged adenomatous polyposis coli, BRAF, Cancer stem cell, cell cycle, cell growth, Colon Cancer, crypt, Genetics, KrasG12D, MEK, mouse model, neoplasm, oncogene, progression, proximal colon, rectal cancer, regulation, serrated, signal transduction, tumorigenesis Leave a comment
Who Will Develop Colorectal Cancer at a Young Age?
A screen for mutations in mismatch repair (MMR) genes could be used to identify young people at risk for colorectal cancer, report Paul Limburg et al. in the June issue of Clinical Gastroenterology and Hepatology. It is a challenge to … Continue reading
Posted in Cancer, GI Tract Tagged cancer risk, Colon Cancer, DNA mismatch repair genes, early-onset, Genetics, mutant, risk, susceptibility Leave a comment
Which Patients with Cystic Fibrosis are at Greatest Risk for Pancreatitis?
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause well-known lung defects, but in the January issue of Gastroenterology, Chee Y. Ooi et al. describe specific CFTR genotypes that increase risk for pancreatitis. Most patients with cystic fibrosis that … Continue reading
Posted in Pancreas Tagged Genetics, Lung Disease, Modifier, Pancreas 2 Comments
Eating Away at Crohn’s Disease
Genetic features of many patients with Crohn’s disease affect the ability of their intestinal cells to undergo autophagy—a form of self-digestion that allows them to fight pathogenic bacteria, according to a study by Craig Homer et al. in the November … Continue reading
Posted in GI Tract Tagged CARD15, Genetics, Inflammatory Bowel Disease, Mucosal Immunity 3 Comments