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Tag Archives: HCV
Mapping HCV Infection in the Liver
Using single-cell laser capture and high-resolution analysis, researchers show that hepatitis C virus (HCV) infects hepatocytes in the human liver in nonrandom clusters, whereas expression of anti-viral molecules is scattered among hepatocytes. The findings are presented in the December issue … Continue reading
Posted in Liver/Biliary
Tagged cell-cell, clinical specimen, control, HCV, hepatitis C, infection, ISG, liver, mechanism, microscopy, propagation, replication, spread, transmission, vRNA
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Are Patients Receiving the Latest Anti-HCV Drugs?
Less than 20% of patients infected with the most common Hepatitis C virus (HCV) genotype receive the latest drugs approved by the US Food and Drug Administration (FDA), according to the August issue of Clinical Gastroenterology and Hepatology. This low … Continue reading
Posted in Liver/Biliary, Technology
Tagged Cirrhosis, clinical tirial, DAA, direct-acting anti-viral agent, drug, Fibrosis, HCV, hepatitis, liver, patient management, therapy, treatment, virus
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Is SVR12 As Good As SVR24?
In patients with chronic Hepatitis C virus (HCV) infection, a sustained viral response to treatment regimens 12 weeks after therapy (SVR12) is a good indicator that the response will be maintained until week 24 (SVR 24), based on an analysis of … Continue reading
Posted in Liver/Biliary, Technology
Tagged blood level, Clinical Trial, cure, DAA, follow-up, HCV, HCV RNA, hepatitis C virus, Peg-Ifn, respones, sustained, therapy, treatment, virus
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New Ways to Study HCV, Genotypes 3 and 4
Researchers can now study replication of Hepatitis C virus genotypes 3 and 4 in cultured cells, described in 2 articles in the January issue of Gastroenterology. These new tools will improve our understanding of how they cause liver disease, and … Continue reading
Posted in Liver/Biliary, Technology
Tagged antiviral, assay, Cirrhosis, DAA, drug testing, experimental system, HCV, hepatitis C virus, in vitro, laboratory, liver disease, model, replication
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It’s Not Easy to Diagnose Intermediate-Stage Liver Fibrosis
Biopsy has a low level of diagnostic performance for liver fibrosis stages F2 and F1. The recommendation for biopsy analysis, instead of non-invasive tests, for diagnosis of intermediate stages of fibrosis is therefore misleading, according to the June issue of … Continue reading
Posted in Liver/Biliary, Technology
Tagged Cirrhosis, diagnostic, HBV, HCV, hepatitis progression, Inflammation, liver disease, pathology anlysis, prognostis, response to therapy, testing
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A Special Issue on Viral Hepatitis
The May issue of Gastroenterology features a very special supplement—“Viral Hepatitis: A Changing Field”—comprising 17 review and commentary articles from international leaders in hepatitis treatment and research. The issue provides insight into the rapid progress made in the treatment and … Continue reading
Posted in Cancer, Liver/Biliary, Technology
Tagged Cirrhosis, editorial, HAV, HBV, HCV, hepatitis, HEV, perspective, review, therapy, treatment, Virology
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Can We Treat Chronic HCV Infection Without Interferon?
A potent combination of 2 drugs that directly target the hepatitis C virus (HCV) is effective in patients with chronic infection, and doesn’t require interferon therapy, according to an article in the December issue of Gastroenterology. Patients infected with HCV … Continue reading
Posted in Liver/Biliary, Technology
Tagged Cirrhosis, Clinical Trial, DAA, direct acting antiviral agent, drug development, Fibrosis, HCV, hepatitis C, liver disease, therapy
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How Does Deferasirox Reduce Liver Fibrosis?
Liver fibrosis is reduced in patients with iron overload β-thalassemia and hepatitis C given the iron chelator deferasirox, according to Yves Deugnier et al. in the October issue of Gastroenterology. The liver is the main site of iron accumulation in … Continue reading
Posted in Liver/Biliary, Technology
Tagged ALT, Cirrhosis, Clinical Trial, HCV, hepatitis, iron, Ishak stage, liver diseaes, outcome, therapy
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Kristine Novak, PhD, Science Editor
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