Tag Archives: IBD

In Treating Crohn’s Disease, Earlier is Better

Patients receiving medical therapies when they have more complicated stages of Crohn’s disease (CD) are more likely to require surgery, researchers report in the March issue of Clinical Gastroenterology and Hepatology. The disease is most-effectively treated by drugs at its … Continue reading

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Are IBD Drugs Safe During Pregnancy?

Researchers find no evidence that inflammatory bowel disease (IBD) during pregnancy, or medical treatment for IBD during pregnancy, increases risk for congenital abnormalities in children. The findings, based on a large database analysis, are published in the January issue of Gastroenterology. … Continue reading

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Are Mitochondria Involved in Ulcerative Colitis?

Changes in mitochondrial DNA that increase levels of ATP in the intestinal mucosa protect mice from colitis, according to the November issue of Gastroenterology. Strategies to increase mitochondrial ATP production by intestinal epithelial cells might therefore be developed to treat patients … Continue reading

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Does Thiopurine Therapy Increase Cancer Risk?

Patients with ulcerative colitis (UC) have a 4-fold increase in risk of lymphoma during treatment with thiopurines, compared to UC patients who have not been treated with these drugs, according to a nationwide cohort study in the November issue of … Continue reading

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Cannabis for Crohn’s Disease?

Eight weeks of therapy with Δ9-tetrahydrocannabinol (THC)-rich cannabis reduced symptoms in patients with active Crohn’s disease, according to a controlled trial published in the October issue of Clinical Gastroenterology and Hepatology. However, these effects were only temporary. The marijuana plant … Continue reading

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Can a microRNA Control Inflammation in Patients With Ulcerative Colitis?

Loss of a non-coding RNA that regulates inflammation could contribute to development of ulcerative colitis (UC) in children, according to the October issue of Gastroenterology. UC and Crohn’s disease are chronic inflammatory bowel diseases that affect adults and children. These … Continue reading

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Are All Patients With IBD at Increased Risk for Colorectal Cancer?

Although inflammatory bowel disease (IBD) increases risk for colorectal cancer (CRC), the risk is only substantial among patients with long-term, extensive colitis. Furthermore, CRC risk is reduced by thiopurine therapy, according to the July issue of Gastroenterology. Laurent Beaugerie et … Continue reading

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How Does PSC Lead to IBD?

Many patients with primary sclerosing cholangitis (PSC) also have inflammatory bowel disease (IBD), which becomes more severe after liver transplantation, researchers report in the May issue of Clinical Gastroenterology and Hepatology. These patients might require special immunosuppressive regimens. PSC is … Continue reading

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What are the Effects of IBD Therapy During Pregnancy?

In pregnant women treated for inflammatory bowel diseases (IBD),  infliximab and adalimumab, but not certolizumab, cross the placenta and are detected in infants up to 6 months after birth, according to the March issue of Clinical Gastroenterology and Hepatology (CGH). However, … Continue reading

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Does Depression Increase the Risk for Inflammatory Bowel Disease?

Depression increases the risk for Crohn’s disease in women, according to a study published in the January issue of Clinical Gastroenterology and Hepatology. Psychological factors might therefore contribute to development of this disorder. Anxiety, depression, and other psychological disorders are … Continue reading

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