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Tag Archives: Inflammatory Bowel Disease
In Treating Crohn’s Disease, Earlier is Better
Patients receiving medical therapies when they have more complicated stages of Crohn’s disease (CD) are more likely to require surgery, researchers report in the March issue of Clinical Gastroenterology and Hepatology. The disease is most-effectively treated by drugs at its … Continue reading
Posted in GI Tract
Tagged anti-TNF, CD, drug, early, IBD, Inflammation, Inflammatory Bowel Disease, late-stage, progression, stricture, sugery, thiopurine, TNF inhibitors, treatment
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Are Mitochondria Involved in Ulcerative Colitis?
Changes in mitochondrial DNA that increase levels of ATP in the intestinal mucosa protect mice from colitis, according to the November issue of Gastroenterology. Strategies to increase mitochondrial ATP production by intestinal epithelial cells might therefore be developed to treat patients … Continue reading
Posted in GI Tract, Technology
Tagged apoptosis, ATP, energy production, IBD, Inflammation, Inflammatory Bowel Disease, intestine, mechanisms, mitochondria, pathogenesis, proliferation, UC, Ulcerative Colitis
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Does Thiopurine Therapy Increase Cancer Risk?
Patients with ulcerative colitis (UC) have a 4-fold increase in risk of lymphoma during treatment with thiopurines, compared to UC patients who have not been treated with these drugs, according to a nationwide cohort study in the November issue of … Continue reading
Posted in Cancer, GI Tract
Tagged 6-mercaptopurine, azathioprine, cancer risk, colitis, DNA, EBV, IBD, immunosuppressant, Inflammatory Bowel Disease, lymphoma, purine, thiopurine
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Cannabis for Crohn’s Disease?
Eight weeks of therapy with Δ9-tetrahydrocannabinol (THC)-rich cannabis reduced symptoms in patients with active Crohn’s disease, according to a controlled trial published in the October issue of Clinical Gastroenterology and Hepatology. However, these effects were only temporary. The marijuana plant … Continue reading
Posted in GI Tract, Technology
Tagged cannabis, Crohn's Disease, IBD, Inflammatory Bowel Disease, intestinal inflammation, marijuana, smoking, THC, therapy, treatment
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Are All Patients With IBD at Increased Risk for Colorectal Cancer?
Although inflammatory bowel disease (IBD) increases risk for colorectal cancer (CRC), the risk is only substantial among patients with long-term, extensive colitis. Furthermore, CRC risk is reduced by thiopurine therapy, according to the July issue of Gastroenterology. Laurent Beaugerie et … Continue reading
Posted in Cancer, GI Tract
Tagged CD, Colon Cancer, Colorectal Cancer, CRC, Crohn's Disease, Epidemiology, IBD, Inflammatory Bowel Disease, risk factor, UC, Ulcerative Colitis
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What are the Effects of IBD Therapy During Pregnancy?
In pregnant women treated for inflammatory bowel diseases (IBD), infliximab and adalimumab, but not certolizumab, cross the placenta and are detected in infants up to 6 months after birth, according to the March issue of Clinical Gastroenterology and Hepatology (CGH). However, … Continue reading
Who Will Develop Pouchitis After Ileal Pouch–Anal Anastomosis?
Serum markers can be used to identify patients with ulcerative colitis most likely to have inflammatory complications after ileal pouch–anal anastomosis (IPAA), according to the May issue of Clinical Gastroenterology and Hepatology. More than 20% of individuals with ulcerative colitis … Continue reading
Is Medicine or Surgery the Best Treatment for Crohn’s Disease?
For patients with Crohn’s disease and intra-abdominal abscesses, nonsurgical and surgical management strategies result in similar rates of abscess recurrence and complications, according to the April issue of Clinical Gastroenterology and Hepatology. Crohn’s disease can progress from inflammation and ulceration … Continue reading
Posted in GI Tract, Technology
Tagged anti-TNF agent, Colon, drug, IBD, Inflammatory Bowel Disease, intestine, Management, therapy, tumor necrosis factor, ulcer
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Can Patients With Crohn’s Disease Ever Stop Taking Infliximab?
Half of patients with Crohn’s disease treated with infliximab experience a relapse within the first year after they stop taking the drug, according to a study published in the January issue of Gastroenterology. Drugs such as infliximab inhibit the inflammatory … Continue reading
Does Mucosal Healing Determine Which Patients Will Recover From Ulcerative Colitis?
Lack of mucosal healing, based on endoscopic analysis, identifies patients with ulcerative colitis (UC) who are not likely to respond to corticosteroid therapy, according to Sandro Ardizzone et al. in the June issue of Clinical Gastroenterology and Hepatology. In a … Continue reading
Kristine Novak, PhD, Science Editor
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