Tag Archives: Obesity

How Does a High-Fat Diet Contribute to Pancreatic Cancer?

Posted on December 5, 2013 by

A high-fat diet can promote development of pancreatic cancer, but cyclooxygenase-2 (COX2) inhibitors prevent this process, according to a mouse study published in the December issue of Gastroenterology. The mechanisms appear to involve activation of oncogenic KRAS and upregulation of … Continue reading →

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How Might Carbonation Contribute to Obesity?

Posted on September 16, 2013 by

Carbonation makes drinks seem less sweet than they really are, and could increase consumption of sugar and food, neuroscientists report in the September issue of Gastroenterology. It might be therefore be best for weight-loss plans to avoid carbonated beverages. Addition … Continue reading →

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Which Patients With Barrett’s Esophagus Will Develop Esophageal Cancer?

Posted on August 5, 2013 by

Researchers have found markers to identify patients with Barrett’s esophagus (BE) at greatest risk of developing esophageal adenocarcinoma. These are described in the August issue of Clinical Gastroenterology and Hepatology. In patients with BE, part of the normal stratified squamous … Continue reading →

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Molecular Mechanisms of Roux-en-Y Gastric Bypass

Posted on February 25, 2013 by

Many of the beneficial effects of Roux-en-Y gastric bypass (RYGB), including improved glucose homeostasis, require the actions of melanocortin-4 receptors (MC4Rs) on autonomic neurons, according to the March issue of Gastroenterology. Fasting glycemia often improves within days of RYGB (see … Continue reading →

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How Common is Portal Hypertension in Patients With NAFLD?

Posted on August 27, 2012 by

Patients with nonalcoholic fatty liver disease (NAFLD) are at risk for portal hypertension and esophageal varices, according to the September issue of Clinical Gastroenterology and Hepatology. The study also shows that factors such as advanced liver disease, type 2 diabetes, … Continue reading →

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Does Menopause Affect Outcomes from Roux-en-Y Gastric Bypass Surgery?

Posted on August 13, 2012 by

Estradiol increases body weight loss and satiation effects of Roux-en-Y gastric bypass (RYGB) in ovariectomized rats, according to the August issue of Gastroenterology. Approximately ~85% of bariatric surgery procedures are performed on women, but little is known about the effects … Continue reading →

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Does the Western Diet Promote Endotoxemia and Inflammation?

Posted on May 21, 2012 by

A high-fat diet can cause endotoxemia, which promotes the systemic inflammation and metabolic disorders associated with obesity, according to a human study published in the May issue of Gastroenterology. Chronic endotoxemia (the presence of endotoxins such as lipopolysaccharide in blood) … Continue reading →

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