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Tag Archives: Pancreatic cancer
How Does a High-Fat Diet Contribute to Pancreatic Cancer?
A high-fat diet can promote development of pancreatic cancer, but cyclooxygenase-2 (COX2) inhibitors prevent this process, according to a mouse study published in the December issue of Gastroenterology. The mechanisms appear to involve activation of oncogenic KRAS and upregulation of … Continue reading
Posted in Cancer, Pancreas Tagged Celecoxib, COX2 inhibitor, diet, Fibrosis, Inflammation, mouse model, Obesity, Pancreatic cancer, PanIN, Prevention, risk factor, tumor progression 1 Comment
How Can We Screen for Pancreatic Cancer and its Precursors?
Individuals with invasive pancreatic cancer or high-grade dysplasia can be identified based on a specific DNA mutation in pancreatic juice samples from the duodena, according to the June issue of Clinical Gastroenterology and Hepatology. Tests for mutant TP53 might be developed to improve the … Continue reading
Posted in Cancer, Pancreas Tagged Pancreatic cancer, risk factor, test Leave a comment
Can We Increase the Sensitivity of Pancreatic Cancer Cells to Chemotherapeutics?
Researchers have identified small molecules that increase the ability of chemotherapeutic agents to kill pancreatic cancer cells and slow tumor growth in mice, according to the February issue of Gastroenterology. One way that chemotherapeutics such gemcitabine, 5-fluorouracil, and platinum-based compounds … Continue reading
Posted in Cancer, Pancreas, Technology Tagged chemotherapy, drug, efficacy, Pancreatic cancer, response, safety, sensitivity, therapy, treatment Leave a comment
Can Imaging Identify the Most Dangerous Pancreatic Cystic Neoplasms?
Endoscopic ultrasound can be used to identify cystic neoplasms of the pancreas that are most likely to become malignant, according to the February issue of Clinical Gastroenterology and Hepatology. Mucus-producing cystic neoplasms of the pancreas, including intraductal papillary mucinous neoplasm … Continue reading
Posted in Cancer, GI Tract, Technology Tagged cysts, diagnostics, neoplasm, Pancreatic cancer, prognosis, radiology, risk factors, Screening, test, Tumor Leave a comment
A Special Issue: the Exocrine Pancreas and its Disorders
Everything you ever wanted to know about the pancreas, its development and function, and the pathogenesis and treatment of its disorders are now covered in a special issue of Gastroenterology. Pancreatology is a rapidly developing field—recent findings from molecular and genetic … Continue reading →