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Tag Archives: pathogenesis
Are Mitochondria Involved in Ulcerative Colitis?
Changes in mitochondrial DNA that increase levels of ATP in the intestinal mucosa protect mice from colitis, according to the November issue of Gastroenterology. Strategies to increase mitochondrial ATP production by intestinal epithelial cells might therefore be developed to treat patients … Continue reading
Posted in GI Tract, Technology
Tagged apoptosis, ATP, energy production, IBD, Inflammation, Inflammatory Bowel Disease, intestine, mechanisms, mitochondria, pathogenesis, proliferation, UC, Ulcerative Colitis
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Can a microRNA Control Inflammation in Patients With Ulcerative Colitis?
Loss of a non-coding RNA that regulates inflammation could contribute to development of ulcerative colitis (UC) in children, according to the October issue of Gastroenterology. UC and Crohn’s disease are chronic inflammatory bowel diseases that affect adults and children. These … Continue reading
Posted in GI Tract, Technology
Tagged causes, CD, Colon, gene regulation, IBD, Inflammation, mechanisms, microRNA, miRNA, mRNA, pathogenesis, post-transcriptional modification, RNA processing, translation, treatment, UC
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How Does PSC Lead to IBD?
Many patients with primary sclerosing cholangitis (PSC) also have inflammatory bowel disease (IBD), which becomes more severe after liver transplantation, researchers report in the May issue of Clinical Gastroenterology and Hepatology. These patients might require special immunosuppressive regimens. PSC is … Continue reading
What is Intrahepatic Cholangiocarcinoma?
Researchers have found that intrahepatic cholangiocarcinomas (ICCs) are really 2 different groups of tumors, based on molecular and genetic analyses, reported in the April issue of Gastroenterology. These findings identify class-specific mechanisms of oncogenesis that could lead to new treatment approaches … Continue reading
Posted in Cancer, Liver/Biliary
Tagged cancer-causing, cholangiocarcinoma, deletions, difference, Genetics, genomics, ICC, Liver Cancer, mechanisms, mutations, oncogenes, Oncogenesis, pathogenesis, Tumor
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A Rare, Autoimmune Cause of Intractable Nausea and Vomiting
Some cases of unexplained, intractable vomiting are caused by an autoimmune disorder in which patients develop antibodies against the brain protein astrocytic aquaporin-4 (AQP4), according to the March issue of Clinical Gastroenterology and Hepatology. AQP4 is a water channel in … Continue reading
Posted in GI Tract
Tagged autoimmune disease, brain, cause, etiology, nausea, nervous system, neurologic, neurology, pathogenesis, vomiting, water channel
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What Can We Learn from a Pig Model of FAP?
A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged Animal Model, Colon Cancer, CRC, intestinal cancer, mechanism, mouse model, pathogenesis, preclinical, treatment, Tumor
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Origins of Gastric Cancer
Gastric tumors can arise from a single mutation in a single stomach gland, according to Lydia Gutierrez-Gonzalez et al. in the April issue of Gastroenterology. To study how gastric dysplasias form and expand, Gutierrez-Gonzalez et al. analyzed 23 samples of … Continue reading
Posted in Cancer, GI Tract
Tagged Neoplasia, Oncogenesis, pathogenesis, Stomach Cancer, Tumor Development
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Which Roads Lead to NASH?
Which Roads Lead to NASH? The progressive liver disease nonalcoholic steatohepatitis (NASH) is mediated by an innate immune response in the liver that causes tissue damage and fibrosis. The innate immune system protects against invading pathogens, but it’s not clear … Continue reading
Kristine Novak, PhD, Science Editor
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