Tag Archives: pathogenesis

Are Mitochondria Involved in Ulcerative Colitis?

Changes in mitochondrial DNA that increase levels of ATP in the intestinal mucosa protect mice from colitis, according to the November issue of Gastroenterology. Strategies to increase mitochondrial ATP production by intestinal epithelial cells might therefore be developed to treat patients … Continue reading

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Can a microRNA Control Inflammation in Patients With Ulcerative Colitis?

Loss of a non-coding RNA that regulates inflammation could contribute to development of ulcerative colitis (UC) in children, according to the October issue of Gastroenterology. UC and Crohn’s disease are chronic inflammatory bowel diseases that affect adults and children. These … Continue reading

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How Does PSC Lead to IBD?

Many patients with primary sclerosing cholangitis (PSC) also have inflammatory bowel disease (IBD), which becomes more severe after liver transplantation, researchers report in the May issue of Clinical Gastroenterology and Hepatology. These patients might require special immunosuppressive regimens. PSC is … Continue reading

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What is Intrahepatic Cholangiocarcinoma?

Researchers have found that intrahepatic cholangiocarcinomas (ICCs) are really 2 different groups of tumors, based on molecular and genetic analyses, reported in the April issue of Gastroenterology. These findings identify class-specific mechanisms of oncogenesis that could lead to new treatment approaches … Continue reading

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A Rare, Autoimmune Cause of Intractable Nausea and Vomiting

Some cases of unexplained, intractable vomiting are caused by an autoimmune disorder in which patients develop antibodies against the brain protein astrocytic aquaporin-4 (AQP4), according to the March issue of Clinical Gastroenterology and Hepatology. AQP4 is a water channel in … Continue reading

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What Can We Learn from a Pig Model of FAP?

A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop … Continue reading

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Origins of Gastric Cancer

Gastric tumors can arise from a single mutation in a single stomach gland, according to Lydia Gutierrez-Gonzalez et al. in the April issue of Gastroenterology. To study how gastric dysplasias form and expand, Gutierrez-Gonzalez et al. analyzed 23 samples of … Continue reading

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