Tag Archives: PPI

What to do About Gastric Polyps

When clinicians detect a gastric polyp during endoscopy, they are faced with many questions: does the polyp need to be excised, or can a biopsy sample be collected and analyzed? Which polyps should be biopsied? Should patients then be followed, … Continue reading

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Are Patients Who Take Continuous NSAIDs Receiving Gastroprotection?

Among patients who continuously take nonsteroidal anti-inflammatory drugs (NSAIDs), a third of co-prescriptions for drugs to prevent gastrointestinal (GI) damage are not renewed within the next 2 years. This discontinuation increases patients’ risk of stomach pain, inflammation, or ulcers, according … Continue reading

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Can Proton Pump Inhibitors Prevent Esophageal Cancer?

Proton-pump inhibitor (PPI) therapy reduces risk of esophageal cancer in patients with Barrett’s esophagus (BE), according to the April issue of Clinical Gastroenterology and Hepatology. In BE, the squamous epithelium of the distal esophagus is replaced by metaplastic columnar epithelium, … Continue reading

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How Dangerous Are H pylori-Negative Idiopathic Bleeding Ulcers?

Patients with a bleeding peptic ulcer not caused by Helicobacter pylori infection or non-steroidal anti-inflammatory drugs (NSAIDs) are at considerable risk of recurrent bleeding and death. Furthermore, acid-suppressive drugs do not protect these patients, according to the October issue of … Continue reading

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New Word on GERD?

Proton pump inhibitors (PPIs) are useful for treating gastroesophageal reflux disease (GERD), although heartburn completely resolves in only 40% of patients that take these drugs. Furthermore, long-term use of PPIs can increase risk for pneumonia, Clostridium difficile infection, and bone … Continue reading

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