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Tag Archives: signal transduction
Can Circulating Membrane Vesicles Promote Portal Hypertension?
Patients with cirrhosis have a large amount of circulating membrane vesicles—breakdown products from inflammation and liver cell damage. However, these ‘microparticles’ (MPs) are not simply debris; they contribute to the systemic vasodilation and portal hypertension associated with cirrhosis, according to … Continue reading
How Does Aspirin Prevent Cancer?
Aspirin blocks proliferation of colorectal cancer cells and causes them to self destruct by inhibiting the mechanistic target of rapamycin (mTOR), according to the June issue of Gastroenterology. Aspirin is a nonsteroidal anti-inflammatory drug that has been shown in many … Continue reading
Stem Cells Account for Different Fates of Adenomatous and Hyperplastic Polyps
Adenomatous polyps expand the pool of colon stem cells to become malignant, whereas hyperplastic polyps (HPPs) do not, and therefore remain benign, according to a study published in the September issue of Gastroenterology. Many colorectal cancers arise from adenomatous polyps, … Continue reading
Posted in Cancer, GI Tract, Technology
Tagged adenomatous polyposis coli, BRAF, Cancer stem cell, cell cycle, cell growth, Colon Cancer, crypt, Genetics, KrasG12D, MEK, mouse model, neoplasm, oncogene, progression, proximal colon, rectal cancer, regulation, serrated, signal transduction, tumorigenesis
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Kristine Novak, PhD, Science Editor
agajournals.wordpress.com 
A Special Issue: the Exocrine Pancreas and its Disorders
Everything you ever wanted to know about the pancreas, its development and function, and the pathogenesis and treatment of its disorders are now covered in a special issue of Gastroenterology. Pancreatology is a rapidly developing field—recent findings from molecular and genetic … Continue reading →